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Risk Models Table

MODELPROVIDESOUTPUTINCLUDESLINKWHEN TO USE
Gail Personal risk 5-year and lifetime risk (LTR) of developing breast cancer Current age, age at menarche, age at first live birth childbirth, number of first-degree relatives (mother, sisters, daughters) with breast cancer, prior benign biopsies, prior atypical biopsy and race/ethnicity.
DOES NOT INCLUDE: Age of diagnosis of relatives; not to be used to assess “high-risk” criteria for MRI screening
Web:http://www.cancer.gov/bcrisktool/ When considering tamoxifen or other risk-reducing medications (>1.7% 5-year risk); NOT to be used for risk assessment for purposes of screening MRI nor for genetic testing
Tyrer-Cuzick (IBIS) Personal risk and risk of mutation carrier 5-year, 10-year and LTR of developing breast cancer Current age, age at menarche, height, weight, parity, age of first childbirth, age at menopause, HRT use, prior breast biopsy, ovarian cancer, age of dx of breast/ovarian cancer in mother/sister/daughter and if bilateral maternal and paternal grandmothers and aunts; and Ashkenazi descent Web: http://www.ems-trials.org/riskevaluator/ Risk assessment for genetic testing (10% risk for pathogenic mutations is commonly used) or MRI screening (20% lifetime risk threshold)
Penn II Personal risk and risk of mutation carrier LTR risk of developing breast cancer Ashkenazi descent, # of women in family dx with both breast and ovarian cancer, # of women in family dx’ed with ovarian or fallopian cancer in absence of breast cancer (BC), # of BC cases in family diagnosed < age 50, age of youngest BC case in family; # of people in family with: presence of mother-daughter dx, w/ bilateral BC, male BC dx, presence of pancreatic cancer or prostate cancer Web: http://www.afcri.upenn.edu/itacc/penn2/ Risk assessment for genetic testing (10% risk for pathogenic mutations is commonly used) or MRI screening (20% lifetime risk threshold)
Claus Personal risk LTR of developing breast cancer Occurrence(s) of breast cancer in specific female relative(s) Web: http://www.ncbi.nlm.nih.gov/pubmed/8299086 MRI screening (20% lifetime risk threshold)
Breast Cancer Surveillance Consortium (BCSC) Personal risk 5-year and 10-year risk of developing invasive breast cancer Current age, race/ethnicity, BI-RADS breast density, first-degree relative, prior breast biopsy.

Web: https://tools.bcsc-scc.org/BC5yearRisk/calculator.htm
App: https://itunes.apple.com/us/app/bcsc-risk-calculator/id919034661?ls=1&mt

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Risk assessment for use of medications for prevention (tamoxifen, raloxifene, aromatase inhibitors)